Endothelin Receptor Function and Acute Stress (NCT02116335)
🩺 Plain-English Summary (8th-Grade Level)
Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress. This study is an extension of the investigators previous animal work to evaluate the role of endothelin-1 during stress in humans.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (12 items).
Location: Georgia Regents University — Augusta, Georgia
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Having a BMI less than 16 kg/m2 (severely and very severely underweight) or that is greater than 40 kg/m2 (Class III obesity)
- Having evidence of cardiovascular, pulmonary, renal, hepatic, cerebral, or metabolic disease
- Having evidence of pregnancy
- Using medications that affect vascular tone (i.e., nitrates, etc.)
- Postmenopausal women
- Uncontrolled hypertension
- Individuals who are on a restricted salt diet
- Having a history of chronic pain
- Having a history of rheumatoid arthritis
- Using medications that are contraindicated with bosentan (i.e. glyburide, cyclosporine)
- Liver dysfunction (which may be identified with the blood sample we take)
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Georgia Regents University — Augusta, Georgia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.