Who is eligible for clinical trial NCT02532452?

Participants must meet protocol criteria for Viral Infection. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT02532452 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-12-10

Third Party Viral Specific T-cells (VSTs) (NCT02532452)

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Children's Hospital Medical Center, Cincinnati

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to demonstrate that viral specific T-cells (a type of white blood cell) can be generated from an unrelated donor and given safely to patients with viral infections.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (6 items) and avoid the listed exclusions (6 items).

Location: Akron Children's Hospital — Akron, Ohio

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Immunocompromised patient with evidence of viral infection or reactivation
Age \>1 day
Recipients who have had a stem cell transplant must be at least 21 days after stem cell infusion
Clinical status must allow tapering of steroids to \< 0.5mg/kg prednisone or other steroid equivalent
Must be able to receive CTL infusion in Cincinnati
Informed consent obtained by PI or sub-investigator either in person or by phone

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Active acute GVHD grades II-IV
Uncontrolled bacterial or fungal infection
Uncontrolled relapse of malignancy requiring treatment with chemotherapy
Infusion of ATG or alemtuzumab within 2 weeks of VST infusion
Biopsy confirmed acute rejection of solid organ transplant OR empiric treatment of suspected but not confirmed acute rejection of solid organ transplant within the last 30 days

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (4 Sites)

Akron Children's Hospital — Akron, Ohio
University of Cincinnati Medical Center — Cincinnati, Ohio
Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio
The Ohio State University Wexner Medical Center - James Cancer Hospital — Columbus, Ohio

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗