Who is eligible for clinical trial NCT02676739?

Participants must meet protocol criteria for Multiple Sclerosis. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT02676739 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2024-10-15

Adderall XR and Cognitive Impairment in MS (NCT02676739)

🔵 Active, Not Recruiting Phase2 / Phase3 💊 Investigational Drug / Biologic Sponsor: Sarah Morrow

🩺 Plain-English Summary (8th-Grade Level)

This 12 week randomized placebo-controlled study will compare the effects of 10 mg and 20 mg of a mixed amphetamine salt, extended release medication (trade name Adderall XR) to placebo on objective measures of processing speed and memory, as well as on self-reported measures of cognition and quality of life. To be enrolled in the study, MS subjects must demonstrate impaired processing speed on the Symbol Digit Modalities Test (SDMT).

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (8 items) and avoid the listed exclusions (24 items).

Location: Kaye Edmonton Clinic — Edmonton, Alberta

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

MS of any type as per 2010 McDonald's criteria
Males/females between the ages of 18-59, inclusive
Have not received corticosteroids or experienced a relapse in the last ninety days
An Expanded Disability Status Scale (EDSS) of ≤ 7.0
If female, must neither be pregnant nor breast-feeding (pregnancy test to be complete at enrollment for those of childbearing potential)
Willingness to use appropriate contraceptive measures (hormonal contraceptives (i.e., oral contraceptives, patch, vaginal ring, injectables or implants); intrauterine device or system; vasectomy or tubal ligation) both males and females at least 28 days before, for the duration of the trial and for at least 30 days after the study ends unless post-menopausal (no menses for 12 months) or surgically sterile female (complete hysterectomy, bilateral salpingectomy, or tubal ligation with documentation) or vasectomised male partner (with appropriate documentation of azoospermia).
Ability to complete the neuropsychological tests included in the battery including binocular visual acuity of ≤ 20/70 corrected or uncorrected
Stable medications for over the last 30 days with no planned change for the duration of the study.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Evidence of other medical potential cause(s) of cognitive deficits such ADHD, TBI, Alzheimer's disease or other dementia, stroke, previous chronic CNS infection or other neurological disorders
Evidence of untreated major depression as by clinician interview or patient report
Family history of suicide, major depression, or bipolar disorder
Uncontrolled or labile hypertension (\> 135/85 mmHg), treated or untreated
History of structural heart disease, including atherosclerosis or angina
Diagnosis of bipolar disorder or a history of a psychotic episode
Daily opioid use
Daily benzodiazepine use other than nightly administration
Use of other amphetamine or other sympathomimetic medication
Use of naturally grown medicinal or non-medicinal marijuana more than 3x/week or 14x/month
those with Hyperthyroidism or Glaucoma

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (3 Sites)

Kaye Edmonton Clinic — Edmonton, Alberta
London Health Sciences Centre — London, Ontario
Sunnybrook Health Sciences Centre — Toronto, Ontario

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗