Who is eligible for clinical trial NCT03281889?

Participants must meet protocol criteria for Brain Tumor. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT03281889 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-04

Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation (NCT03281889)

🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: Massachusetts General Hospital

🩺 Plain-English Summary (8th-Grade Level)

This research study is studying proton radiation as a possible treatment for brain tumor that requires radiation. The radiation involved in this study is: -Proton Radiation

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (6 items).

Location: Massachusetts General Hospital — Boston, Massachusetts

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Age ≥ 3 years and ≤ 18 years at the time of registration
Histologically proven malignancy necessitating cranio-spinal irradiation. This will include patients with a diagnosis of medulloblastoma, Supratentorial primitive neuroectodermal tumor (SPNET), germ cell tumor (GCT), disseminated ependymoma, embryonal tumor with abundant neuropil and true rosettes (ETANTR), Atypical Teratoid/Rhabdoid Tumor (ATRT), and disseminated low-grade glioma (LGG).
Life expectancy ≥ 12 months.
Signed informed consent document and assent when appropriate.
HGB of \> 10 g/L and PLT count \> 80 K/uL

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Any prior therapeutic radiation therapy \> 500 cGy has been delivered.
Individuals with a history of a different malignancy are ineligible except for the following circumstances: if they have been disease-free for at least 5 years and are deemed by the investigator to be a low-risk for recurrence of that malignancy; or, have had only cervical cancer in situ, or basal cell or squamous cell carcinoma of the skin.
Any major uncontrolled or poorly controlled intercurrent illness that would limit compliance with study requirements.
Pregnant females are excluded. Females of childbearing age/menstruating must confirm that either they are not sexually active or have a negative pregnancy test prior to initiation of radiation therapy.
Patients that receive concurrent chemotherapy with the exception of concurrent Vincristine.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (2 Sites)

Massachusetts General Hospital — Boston, Massachusetts
MD Anderson Cancer Center — Houston, Texas

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗