Who is eligible for clinical trial NCT03459456?

Participants must meet protocol criteria for OCD. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT03459456 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-08-14

Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE) (NCT03459456)

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Baylor College of Medicine

🩺 Plain-English Summary (8th-Grade Level)

The investigators propose to synchronize automated measurements of behavior - head, body, and face dynamics, gaze, and vocal prosody - with simultaneous recordings of brain activity in clinically relevant contexts.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (4 items).

Location: University of Pittsburgh — Pittsburgh, Pennsylvania

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

OCD subjects:
The subject has a minimum score of ≥16 on the Y-BOCS;
If applicable, on a stable pharmacologic regimen;
Sample will be enriched with OCD subjects having contamination obsessions and handwashing compulsions, and scores on items 9 and 10 of the Y-BOCS reflecting difficulty resisting and controlling compulsions; Healthy Control Subjects:
Men and women will be age/gender matched with subjects
Absence of any psychiatric disorder determined by the MINI\^53 for DSM-5 with the exception of non-impairing specific phobia.
Low scores on measures of contamination concerns and disgust sensitivity based on Y-BOCS scores below 10 and the Disgust Scale-Revised (total score \<8).

Usually NOT eligible if any of the following apply:

Exclusion Criteria: OCD Subjects:
Subject has a documented lifetime diagnosis of psychotic disorders such as schizophrenia;
Alcohol or substance abuse/dependence reported within 6 months, excluding nicotine;
The subject is deemed at high risk of suicidal behavior or impulsivity. The Beck Depression Inventory\^52 (BDI) will be completed by all subjects and responses reviewed by a clinician. Healthy Control Subjects: \- Those not meeting the inclusion criteria described in the inclusion section above.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (3 Sites)

University of Pittsburgh — Pittsburgh, Pennsylvania
Brown University — Providence, Rhode Island
Baylor College of Medicine — Houston, Texas

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗