🏛️ Verified NIH Record • Updated 2024-10-01

Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE (NCT03581877)

🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: Northwell Health

🩺 Plain-English Summary (8th-Grade Level)

To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive pulmonary embolism (PE)

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (24 items).

Location: Southside Northwell Hospital — Bay Shore, New York

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • Age \<18 to age \>90 years;
  • PE symptom duration \>14 days;
  • Administration of thrombolytic drugs in the last 4 days
  • Contraindications to thrombolytic therapy:
  • Active bleeding disorder or coagulation disorder;
  • Platelet count \<100 000/mm3
  • Hematocrit \< 30%
  • INR\> 3
  • Previous history of vitamin K antagonists with international normalized ratio \>2.5 on admission
  • History of intracranial or intraspinal surgery or trauma or intracranial/intraspinal bleeding
  • Intracranial neoplasm

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (2 Sites)

  • Southside Northwell Hospital — Bay Shore, New York
  • Long Island Jewish Medical Center — Queens, New York

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗