Hypovolemic Phlebotomy to Reduce Blood Transfusions in Major Hepatic Resections (NCT03651154)
🩺 Plain-English Summary (8th-Grade Level)
Major liver resection is associated with substantial intraoperative blood loss and subsequently blood transfusions. Blood transfusion in elective liver surgery is a significant factor of perioperative morbidity and mortality, as well as possibly long-term oncologic outcome. The purpose of this study is to use whole blood phlebotomy to decrease the central venous pressure, resulting in a state of relative hypovolemia. It is hypothesized that this intervention will lead to a decrease in blood loss at the time of liver resection and thus reduced blood transfusion in major liver surgeries.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (2 items) and avoid the listed exclusions (14 items).
Location: Vancouver General Hospital — Vancouver, British Columbia
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Age \<18 years
- Preoperative hemoglobin \<100g/L
- GFR clearance \<60mL/min
- Abnormal coagulation parameters (not on warfarin and/or platelets count \<100 X10\^9/L)
- Evidence of hepatic metabolic disorder
- Active cardiac conditions: Unstable coronary syndromes; Severe valvular disease; and Myocardial infarction within 6 months prior to surgery
- History of significant cerebrovascular disease: Patients with clinically-significant stroke/CVA within the past 6 months or severe carotid stenosis (defined as \>70%)
- History of significant peripheral vascular disease: Non-revascularized with regular/ongoing claudication
- Pregnancy
- Refusal of blood products
- Presence of active infection
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (4 Sites)
- Vancouver General Hospital — Vancouver, British Columbia
- The Ottawa Hospital — Ottawa, Ontario
- Centre Hospitalier de l"Université de Sherbrooke — Montreal, Quebec
- Centre Hospitalier de l'Université de Montréal — Montreal, Quebec
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.