🏛️ Verified NIH Record • Updated 2026-06-05

Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance (NCT03756480)

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Johns Hopkins University

🩺 Plain-English Summary (8th-Grade Level)

This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic endometrium.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (8 items).

Location: Yale School of Medicine — New Haven, Connecticut

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • Use of any kind of steroidal therapy including oral contraceptives, Norplant, estrogen replacement/supplemental therapy, androgens (Danazol, Cyclomen, Danocrine, testosterone) or progesterone. She may not be taking or be on Celebrex.
  • Pregnant.
  • Presence of pelvic infection.
  • Mullerian anomalies with absence of a cervix.
  • History of cancer of the reproductive tract.
  • Presence of undiagnosed uterine bleeding.
  • Treatment with intrauterine device (IUD) or progestin-containing intrauterine device.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (3 Sites)

  • Yale School of Medicine — New Haven, Connecticut
  • Johns Hopkins Hospital — Baltimore, Maryland
  • Vanderbilt University Medical Center — Nashville, Tennessee

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗