🏛️ Verified NIH Record • Updated 2026-02-23

MRI Guided SBRT for Localized Prostate Cancer (NCT03778112)

🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: Rush University Medical Center

🩺 Plain-English Summary (8th-Grade Level)

This study utilizes advanced imaging techniques (mpMRI prostate scan) to select and stratify patients for two different radiotherapy regimens based on the presence/absence of identifiable intraprostatic lesions. In patients without identifiable prostate cancer lesions, SBRT to the prostate in 5 sessions (fractions) will be administered. In patients with MRI-identified lesion(s), pelvic IMRT in 25 fractions will be administered followed by an SBRT prostate boost while simultaneously treating the prostate cancer lesion(s) to a higher dose in 3 fractions.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (10 items).

Location: Rush University Medical Center — Chicago, Illinois

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • Prior or concurrent invasive malignancy (except non-melanoma skin cancer)
  • Regional Lymph Node (N1) involvement
  • Distant Metastases (M1) involvement
  • History of prior pelvic irradiation (external beam radiotherapy or brachytherapy)
  • Prior chemotherapy
  • Severe, active co-morbidities (unstable angina and/or CHF; MI; COPD; liver disease; AIDS)
  • Acute bacterial or fungal infection requiring IV antibiotics
  • Inability to undergo MRI
  • Inability to receive fiducial markers

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

  • Rush University Medical Center — Chicago, Illinois

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗