Who is eligible for clinical trial NCT03998202?

Participants must meet protocol criteria for Colorectal Cancer. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT03998202 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-01-07

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer (NCT03998202)

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Wake Forest University Health Sciences

🩺 Plain-English Summary (8th-Grade Level)

This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (6 items) and avoid the listed exclusions (6 items).

Location: Beebe South Coastal Health Campus — Millville, Delaware

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Newly diagnosed metastatic CRC or newly recognized metastatic recurrence of CRC \>= to 3 months (12 weeks) from completion of treatment of non-metastatic CRC.
Planning to or recently started to undergo undergo immunotherapy and/or 5-FU based chemotherapy as a first line of treatment. 5-FU chemotherapy can be 5-FU alone or in combination with oxaliplatin and/or irinotecan +/- immunotherapy. Capecitabine is also acceptable.
Estimated life expectancy \>= 6 months.
Patients must be able to comprehend English or Spanish (for questionnaire completion).
Ability to understand and the willingness to sign a written informed consent document.
Patient eligibility is not dependent on BMI or weight. Patients with a significant (+- \> 10%) body weight change in the previous 12 months are eligible for this study.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Patients enrolled on hospice.
Prior systemic chemotherapy for metastatic colorectal cancer (ok if adjuvant chemotherapy completed \>= 3 months (12 weeks) prior to this disease disease recurrence and treatment).
Patients may not be receiving any other investigational agents.
No untreated brain metastases. Patients with treated brain metastases are eligible.
Patients on or planned to undergo radiation therapy in near future.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (146 Sites)

Beebe South Coastal Health Campus — Millville, Delaware
Helen F Graham Cancer Center — Newark, Delaware
Medical Oncology Hematology Consultants PA — Newark, Delaware
Beebe Health Campus — Rehoboth Beach, Delaware
Christiana Care Health System-Wilmington Hospital — Wilmington, Delaware
MedStar Georgetown University Hospital — Washington D.C., District of Columbia
John B Amos Cancer Center — Columbus, Georgia
Illinois CancerCare-Bloomington — Bloomington, Illinois
Illinois CancerCare-Canton — Canton, Illinois
SIH Cancer Institute — Carterville, Illinois
John H Stroger Jr Hospital of Cook County — Chicago, Illinois
Carle at The Riverfront — Danville, Illinois
Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois
Crossroads Cancer Center — Effingham, Illinois
Illinois CancerCare-Galesburg — Galesburg, Illinois
Carle Physician Group - Mattoon/Charleston — Mattoon, Illinois
SSM Health Good Samaritan — Mount Vernon, Illinois
Carle BroMenn Medical Center — Normal, Illinois
Carle Cancer Institute Normal — Normal, Illinois
Cancer Care Center of O'Fallon — O'Fallon, Illinois
Illinois CancerCare-Ottawa Clinic — Ottawa, Illinois
Illinois CancerCare-Pekin — Pekin, Illinois
Illinois CancerCare-Peoria — Peoria, Illinois
Illinois CancerCare-Peru — Peru, Illinois
Southern Illinois University School of Medicine — Springfield, Illinois

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗