Metformin in Alzheimer's Dementia Prevention (NCT04098666)

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

1. Diagnosis of aMCI: in general, the diagnosis of aMCI follows the definition in the 2011 National Institute on Aging (NIA)/ Alzheimer's association (AA) guidelines, without biomarkers. Participants must have:
2. Subjective memory concerns reported by participant, study partner, or clinician.
3. A mini-mental state exam between ≥ 22 for subjects with more than 8 years of education. For subjects with less than 8 years of education, a MMSE ≥ 20 will be allowed.
4. Clinical Dementia Rating = 0.5. The memory box score must be at least 0.5. Information from the formal University of Washington CDR instrument, report by the participant of subjective cognitive complaints, and findings from the screening neuropsychological battery, can be used for this determination by the investigative team. For example, the University of Washington CDR can be 0, but the CDR memory box score can be deemed to be 0.5 based on cognitive complaints at screening and meeting the MCI neuropsychological criteria.
5. General cognition and functional performance sufficiently preserved such that a diagnosis of Alzheimer's disease cannot be made by the site physician at the time of the screening visit.
6. Abnormal memory function documented by scoring within the education adjusted ranges on the Logical Memory II subscale (Delayed Paragraph Recall, Paragraph A only) from the Wechsler Memory Scale-Revised.
7. For early MCI:
8. 9-11 for 16 or more years of education
9. 5-9 for 8-15 years of education
10. 3-6 for 0-7 years of education
11. For late MCI
12. ≤ 8 for 16 or more years of education

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (22 Sites)

• University of California - Irvine — Irvine, California
• Stanford University — Palo Alto, California
• Georgetown University — Washington D.C., District of Columbia
• University of Miami — Miami, Florida
• Emory University — Atlanta, Georgia
• Rush University Medical Center — Chicago, Illinois
• University of Kansas Medical Center — Wichita, Kansas
• Pennington Biomedical Research Center — Baton Rouge, Louisiana
• Boston University — Boston, Massachusetts
• University of New Mexico — Albuquerque, New Mexico
• University at Buffalo — Buffalo, New York
• New York University Langone Medical Center — New York, New York
• Columbia University Medical Center — New York, New York
• Cornell University — New York, New York
• SUNY Upstate Medical University — Syracuse, New York
• Wake Forest University Health Sciences — Winston-Salem, North Carolina
• University of Cincinnati — Cincinnati, Ohio
• University of Texas - Southwestern Medical Center — Dallas, Texas
• The University of Texas Health Science Center San Antonio — San Antonio, Texas
• Eastern Virginia Medical School — Norfolk, Virginia
• University of Washington — Seattle, Washington
• Medical College of Wisconsin — Milwaukee, Wisconsin

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.