🏛️ Verified NIH Record • Updated 2026-08-20
A Study of LY3295668 Erbumine in Participants With Relapsed/Refractory Neuroblastoma (NCT04106219)
🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Eli Lilly and Company
🩺 Plain-English Summary (8th-Grade Level)
The reason for this study is to see if the study drug LY3295668 erbumine is safe in participants with relapsed/refractory neuroblastoma.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (2 items) and avoid the listed exclusions (8 items).
Location: UCSF Medical Center at Mission Bay — San Francisco, California
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Participants must not have had an allogeneic hematopoietic stem cell, bone marrow, or solid organ transplant.
- Participants must not have untreated tumor that has spread to the brain or spinal cord.
- Participants must not have a serious active disease other than neuroblastoma.
- Participants must not have a condition affecting absorption.
- Participants must not have had prior aurora kinase inhibitor exposure.
- Participants must not have a known allergy to the study treatment.
- Participants must not have symptomatic human immunodeficiency virus (HIV) infection or symptomatic activated/reactivated hepatitis A, B, or C.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (17 Sites)
- UCSF Medical Center at Mission Bay — San Francisco, California
- Children's Hospital Colorado — Aurora, Colorado
- University of Chicago - Comer Children's Hospital — Chicago, Illinois
- Dana-Farber Cancer Institute — Boston, Massachusetts
- Cincinnati Childrens Hospital Medical Center — Cincinnati, Ohio
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania
- Texas Childrens Hospital — Houston, Texas
- Perth Children's Hospital — Perth, Western Australia
- UZ Gent — Ghent, Oost-Vlaanderen
- Centre Leon Berard — Lyon, Auvergne-Rhône-Alpes
- Institut Curie — Paris,
- Universitätsklinikum Köln — Cologne,
- Istituto Nazionale dei Tumori — Milan, Lombardy
- National Cancer Center Hospital — Chuo-ku, Tokyo
- Hospital Universitari Vall d'Hebron — Barcelona, Barcelona [Barcelona]
- Hospital Infantil Universitario Niño Jesús — Madrid,
- Alder Hey Children's Hospital — Liverpool,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.