Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease (NCT04114981)

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

1. PRE-REGISTRATION:
2. Pathology from the resected brain metastasis must be consistent with a non-central nervous system primary site. Patients with or without active disease outside the nervous system are eligible (including patients with unknown primaries), as long as the pathology from the brain is consistent with a non-central nervous system primary site.
3. Three or fewer (i.e. 0 to 3) unresected brain metastases (as defined on the post operative magnetic resonance imaging \[MRI\]) at the time of screening. o Note: Dural based metastases (e.g. commonly seen in breast cancer) are eligible.
4. Unresected lesions must measure \< 4.0 cm in maximal extent on the contrasted post-operative treatment MRI brain scan. The unresected lesions will be treated with SRS as outlined in the treatment section of the concept. o Note: The metastases size restriction does not apply to the resected brain metastasis.
5. One brain metastasis must be completely (gross total resection) resected =\< 30 days prior to pre-registration. o NOTE: May not have had resection of more than one brain metastasis.
6. The resected brain metastasis must measure 2 cm or larger on the pre-operative MRI.
7. Resection cavity must measure \< 5.0 cm in maximal extent and the resection must be complete (gross total resection) on the post-operative MRI obtained =\< 30 days prior to pre-registration.
8. Karnofsky performance status of \>= 60.
9. For women of childbearing potential only, a negative urine or serum pregnancy test done =\< 7 days prior to pre-registration is required.
10. Men and women of childbearing potential must be willing to employ adequate contraception throughout the study and for men for up to 3 months after completing treatment.
11. A female of childbearing potential is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
12. Ability to complete an MRI of the head with contrast.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (232 Sites)

• University of Alabama at Birmingham Cancer Center — Birmingham, Alabama
• Anchorage Radiation Therapy Center — Anchorage, Alaska
• Banner MD Anderson Cancer Center — Gilbert, Arizona
• Banner Thunderbird Medical Center — Glendale, Arizona
• Banner-University Medical Center Phoenix — Phoenix, Arizona
• Mayo Clinic Hospital in Arizona — Phoenix, Arizona
• Mayo Clinic in Arizona — Scottsdale, Arizona
• University of Arizona Cancer Center-North Campus — Tucson, Arizona
• Mercy Hospital Fort Smith — Fort Smith, Arkansas
• NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro — Jonesboro, Arkansas
• UC San Diego Moores Cancer Center — La Jolla, California
• Los Angeles County-USC Medical Center — Los Angeles, California
• USC / Norris Comprehensive Cancer Center — Los Angeles, California
• Epic Care Cyberknife Center — Walnut Creek, California
• University of Colorado Hospital — Aurora, Colorado
• UCHealth Memorial Hospital Central — Colorado Springs, Colorado
• Yale University — New Haven, Connecticut
• Helen F Graham Cancer Center — Newark, Delaware
• Beebe Health Campus — Rehoboth Beach, Delaware
• Boca Raton Regional Hospital — Boca Raton, Florida
• Morton Plant Hospital — Clearwater, Florida
• UM Sylvester Comprehensive Cancer Center at Coral Gables — Coral Gables, Florida
• UM Sylvester Comprehensive Cancer Center at Deerfield Beach — Deerfield Beach, Florida
• Mayo Clinic in Florida — Jacksonville, Florida
• University of Miami Miller School of Medicine-Sylvester Cancer Center — Miami, Florida

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.