Who is eligible for clinical trial NCT04215952?

Participants must meet protocol criteria for Aphasia. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04215952 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-06-25

Semantic Feature Analysis Treatment for Aphasia (NCT04215952)

🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program Sponsor: VA Pittsburgh Healthcare System

🩺 Plain-English Summary (8th-Grade Level)

This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (6 items).

Location: VA Pittsburgh Healthcare System — Pittsburgh, Pennsylvania

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

6 months post-onset of aphasia due to unilateral left-hemisphere (LH) stroke
Independent in activities of daily living (ADLs) necessary to live in community-based housing or available caregiver to assist with ADLs
Medically stable and able to tolerate intensive treatment schedule (e.g. no uncontrolled seizures, difficulty breathing, frequent migraines)
English as a first language
No participation in any other speech-language treatment during this study, including follow-up period
Sufficient auditory comprehension abilities demonstrated during screening
Sufficient naming impairment exhibited during screening

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Right Hemisphere stroke
Neurological disease other than stroke
Significant psychiatric disorder
Severe motor speech disorder
Active substance dependence

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

VA Pittsburgh Healthcare System — Pittsburgh, Pennsylvania

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗