🏛️ Verified NIH Record • Updated 2025-12-05
Mechanism of Action of Transcranial Magnetic Stimulation (NCT04278521)
🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Massachusetts General Hospital
🩺 Plain-English Summary (8th-Grade Level)
This is an observational neuroimaging study assessing the effects of TMS on the brains of patients with unipolar depression.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (5 items).
Location: Massachusetts General Hospital — Boston, Massachusetts
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Comorbid DSM-IV primary diagnoses of schizoaffective disorder, schizophrenia or dementia.
- Substance use disorder (abuse or dependence) with active use within the last 3 months
- Severe or unstable medical illness.
- MRI contraindications as determined by MGH department of radiology.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Massachusetts General Hospital — Boston, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.