Who is eligible for clinical trial NCT04288375?

Participants must meet protocol criteria for Soft Tissue Sarcoma. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04288375 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-02-18

Dose Reduction of Postoperative Radiation for Soft Tissue Sarcoma of the Arms and Legs (NCT04288375)

🔵 Active, Not Recruiting Phase2 📋 Clinical Research Protocol Sponsor: Memorial Sloan Kettering Cancer Center

🩺 Plain-English Summary (8th-Grade Level)

The investigators are doing this study to find out whether lowering the dose of postoperative radiation therapy and targeting a smaller area of tissue for treatment is as effective as the standard dose and volume of radiation therapy to control soft tissue sarcoma after surgery. They also want to find out whether the study approach causes fewer and less severe long-term side effects than the standard approach.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (7 items).

Location: Memorial Sloan Kettering Basking Ridge (All protocol activities) — Basking Ridge, New Jersey

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Patients must be diagnosed with a primary soft tissue sarcoma of the extremity, confirmed by MSKCC pathologic review
Age at the time of enrollment of ≥18 years
Patients must have undergone margin-negative oncologic resection of their primary tumor, as confirmed by MSKCC pathologic review
Patients must be able to start radiation within 3 months from time of surgery °If patient is receiving adjuvant chemotherapy, patient must start RT no longer than 3 months past their chemo treatment.
Female patients of childbearing potential must have a negative serum pregnancy test within 14 days of radiation start (or if urine test, within 24 hours of radiation start)
Sexually active patients of childbearing potential must agree to use effective contraception.
The use of chemotherapy will not be dictated by this trial. Patients are allowed to receive chemotherapy at the discretion of the disease management team (as is standard practice to make individualized decisions for each patient regarding the use of chemotherapy).

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Patients with positive margins after surgical resection as indicated by MSKCC pathologic review
Patients with diagnosis of superficial myxofibrosarcoma with indistinct/infiltrative borders on preoperative MRI16 (see Appendix Figure 1 for reference figure)
Patients with multifocal disease in the extremity
Patients who have received prior radiotherapy at or adjacent to the primary tumor bed
Patients with a differentinvasive cancer requiring active treatment at the time of enrollment.
Patients with any concurrent medical or psychiatric condition or disease which, in the investigator's judgment, would make them inappropriate candidates for entry into this study

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (7 Sites)

Memorial Sloan Kettering Basking Ridge (All protocol activities) — Basking Ridge, New Jersey
Memorial Sloan Kettering Monmouth (All protocol activities) — Middletown, New Jersey
Memorial Sloan Kettering Bergen (All protocol activities) — Montvale, New Jersey
Memorial Sloan Kettering Commack (All protocol activities) — Commack, New York
Memorial Sloan Kettering Westchester (All protocol activities) — Harrison, New York
Memorial Sloan Kettering Cancer Center — New York, New York
Memorial Sloan Kettering Nassau (All protocol activities) — Uniondale, New York

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗