Who is eligible for clinical trial NCT04325958?

Participants must meet protocol criteria for Cannabis. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04325958 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-03-20

Age Differences in the Effects of Cannabis on Simulated Driving (NCT04325958)

🟢 Recruiting Observational / Diagnostic 💊 Investigational Drug / Biologic Sponsor: Centre for Addiction and Mental Health

🩺 Plain-English Summary (8th-Grade Level)

Epidemiological studies suggest that the use of cannabis is associated with an increase in the risk of motor vehicle collisions. It is also known that younger users may be at increased risk for motor vehicle collisions. Further, the frequency with which cannabis is used may be an important variable in determining the effects of cannabis on driving. The purpose of the present study will be to investigate the effects of cannabis on simulated driving in young as compared to middle-aged drivers. Half of the participants will be occasional users of cannabis and half will be frequent users of cannabis.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (11 items).

Location: Centre for Addiction and Mental Health — Toronto, Ontario

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

19-25 or 35-45 years of age;
Use of smoked cannabis at least once in the past 6 months.
Use of smoked or vaped cannabis primarily for recreational purposes on up to 1 day per week or on at least 6 days per week in the past 3 months;
Holds a class G or G2 Ontario driver's licence (or equivalent from another jurisdiction) for at least 12 months;
Willing to abstain from using alcohol for 24 hours and cannabis for 72 hours prior to Practice and Test Sessions;
Willing to abstain from all other drugs not prescribed for medical purposes for 48 hours prior to Practice and Test Sessions;
Resides within Toronto (study site) or can reside with friends/family in Toronto after a Test Session; this area may be extended to the Greater Toronto area if recruitment challenges arise;
Participant willing to use appropriate contraception until their participation in the study is completed;
Provides written and informed consent.

Usually NOT eligible if any of the following apply:

Exclusion Criteria
Use of cannabis primarily for therapeutic purposes, or equally for therapeutic and recreational purposes;
Diagnosis of medical condition that contraindicates use of cannabis determined by self-report as judged by the Principal Investigator and a study physician; this includes a history of hypersensitivity to cannabinoids smoke, respiratory disease and/or severe cardiovascular, cerebrovascular, renal or liver disease, and bleeding disorders. Smoking cannabis is not recommended for individuals with respiratory diseases, and they will be excluded;
Diagnosis of psychiatric condition that contraindicates use of cannabis determined by self-report or SCID-5;
Participants of childbearing potential: Pregnancy (point-of-care test) or breastfeeding;
Meets criteria for current or lifetime alcohol or other substance use disorder (DSM-5), except tobacco use disorder and caffeine use disorder;
Is a regular user of medications that affect brain function (based on self-report); this includes concomitant therapy with sedative-hypnotics or other psychoactive drugs
Use of anti-hypertensives;
First-degree relative diagnosed with schizophrenia or another psychotic disorder.
Participation in a past driving study at CAMH (to limit practice effects).
Participation in a clinical study concurrent with their participation in this study.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Centre for Addiction and Mental Health — Toronto, Ontario

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗