Who is eligible for clinical trial NCT04391335?

Participants must meet protocol criteria for Bronchiolitis Obliterans Syndrome. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04391335 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-02-26

Novel Pulmonary Function Measures for Diagnosis of Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem-Cell Transplantation in Children (NCT04391335)

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: The Hospital for Sick Children

🩺 Plain-English Summary (8th-Grade Level)

In this study, we will study 129Xe-MRI and LCI as tools for diagnosis of BOS in pediatric patients who have received Hematopoietic Stem Cell Transplantation (HSCT) and have been identified as eligible for this study. Participants will be required to have vital signs collected, complete breathing tests and complete an MRI. The MRI will require participants to perform breath holds in the MRI scanner with xenon gas while being coached by a research assistant.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (6 items) and avoid the listed exclusions (5 items).

Location: The Hospital for Sick Children — Toronto, Ontario

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Male and female participants aged 6 -17.9 years old.
Received HSCT treatment at least 6 months prior to enrollment in study.
Participants should have an FEV1%pred value greater than 40%.
Participant understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent or assent.
Participant must be able to perform a breath hold for 16s.
Participant meets MRI screening criteria

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Participant has had a cold or respiratory infection in the last four weeks.
Participant requires supplemental oxygen or has a daytime room air oxygen saturation ≤ 95%.
Participant is unable to perform spirometry or plethysmography maneuvers.
Participant is pregnant or lactating.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

The Hospital for Sick Children — Toronto, Ontario

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗