🏛️ Verified NIH Record • Updated 2026-08-10

A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2) (NCT04437511)

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Eli Lilly and Company

🩺 Plain-English Summary (8th-Grade Level)

The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease. Additional participants will be enrolled to an addendum safety cohort. The participants will be administered open-label donanemab. Trial participants who were dosed with donanemab in the main study will be enrolled to a 3-year follow up addendum. No study drug will be administered during this follow up.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (3 items).

Location: Gilbert Neurology — Gilbert, Arizona

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • Contraindication to MRI or PET scans
  • Current treatment with immunoglobulin G (IgG) therapy

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (274 Sites)

  • Gilbert Neurology — Gilbert, Arizona
  • Xenoscience — Phoenix, Arizona
  • Banner Alzheimer's Institute — Phoenix, Arizona
  • Perseverance Research Center — Scottsdale, Arizona
  • Banner Sun Health Research Institute — Sun City, Arizona
  • Banner Alzheimer's Institute Tucson — Tucson, Arizona
  • Center for Neurosciences — Tucson, Arizona
  • Health Initiatives Research — Fayetteville, Arkansas
  • North County Neurology Associates — Carlsbad, California
  • Wr- Pri, Llc — Encino, California
  • Neuro-Pain Medical Center — Fresno, California
  • Neurology Center of North Orange County — Fullerton, California
  • Irvine Clinical Research — Irvine, California
  • Kaizen Brain Center — La Jolla, California
  • Senior Clinical Trials, Inc. — Laguna Hills, California
  • Collaborative Neuroscience Research, LLC — Los Alamitos, California
  • USC Keck School of Medicine — Los Angeles, California
  • Clinical Research Institute — Los Angeles, California
  • Neurovations — Napa, California
  • Hoag Memorial Hospital Presbyterian — Newport Beach, California
  • Stanford Neuroscience Health Center — Palo Alto, California
  • SC3 Research - Pasadena — Pasadena, California
  • PCND Neurology — Poway, California
  • Anderson Clinical Research — Redlands, California
  • Artemis Institute for Clinical Research — San Diego, California

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗