🏛️ Verified NIH Record • Updated 2026-04-29
Biomarkers in the Brain Oxygen Optimization in Severe Traumatic Brain Injury Trial (NCT04565119)
🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: University of Pennsylvania
🩺 Plain-English Summary (8th-Grade Level)
BioBOOST is a multicenter, observational study of the effect of derangements in brain physiologic parameters on brain injury biomarker levels in patients with severe traumatic brain injury.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (3 items).
Location: University of Michigan — Ann Arbor, Michigan
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Profoundly anemic (subjects who are profoundly anemic require blood transfusion)
- Age less than 18 years
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (2 Sites)
- University of Michigan — Ann Arbor, Michigan
- Penn Presbyterian Medical Center — Philadelphia, Pennsylvania
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.