Improving Pain Management Via Spinal Cord Stimulation and Blood Pressure Reduction (NCT04676399)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study (PASSION study) is to monitor symptoms of chronic pain before and after 2 weeks of a standard drug commonly used to treat elevated blood pressure compared with 2 weeks of placebo (crossover design) so that we may better understand how blood pressure affects your level of pain. This study is not testing an experimental drug.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (8 items) and avoid the listed exclusions (16 items).
Location: The Marc A. Asher Comprehensive Spine Center at the Kansas University Medical Center — Kansas City, Kansas
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Any history of abnormal responses (allergy) to thiazide-type drugs
- Currently taking any antihypertensive medication
- Stage 1 hypertension (BP 130-139/80-89 mmHg) with ASCVD risk \<10%
- BP ≥160/100 (these patients should be promptly treated with 2 medications)
- Secondary hypertension (e.g., aldosteronism, renal artery stenosis)
- Symptomatic hypotension (weakness or syncope upon standing)
- Renal failure
- Diabetes requiring insulin or glucose-lowering drugs
- History of neurological disease (e.g., dementias, Parkinson's)
- History of stroke
- Current diagnosis of cancer
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- The Marc A. Asher Comprehensive Spine Center at the Kansas University Medical Center — Kansas City, Kansas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.