Who is eligible for clinical trial NCT04772456?

Participants must meet protocol criteria for Glioma. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04772456 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-09-16

Hyperpolarized 13C-pyruvate Metabolic MRI With Infiltrating Gliomas (NCT04772456)

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: University of Maryland, Baltimore

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to examine the safety and feasibility of performing hyperpolarized metabolic MRI in the diagnosis of brain tumor. This study will also assess the accuracy of hyperpolarized metabolic MRI to diagnose intermediate to patients with infiltrating gliomas and examine the added utility of metabolic MRI over standard MRI imaging The FDA is allowing the use of hyperpolarized \[1-13C\] pyruvate (HP 13C-pyruvate) in this study. Up to 5 patients may take part in this study at the University of Maryland, Baltimore (UMB).

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (3 items).

Location: Rosy Njonkou Tchoquessi — Baltimore, Maryland

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

• Patients with a new brain lesion interpreted as suspected infiltrating gliomas including but not limited to (diffuse astrocytoma WHO grade 2; oligodendroglioma WHO grade 2 and 3; anaplastic astrocytoma WHO grade 3; astrocytoma WHO grade 4), OR, patients with prior history of infiltrating glioma scheduled for surgery for tumor biopsy or resection.
Ages 18-80, including male and female
Suitable to undergo contrast-enhanced MRI
Negative serum pregnancy test

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Inability to undergo MRI scan
Inability to receive IV contrast secondary to severe reaction or renal insufficiency.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Rosy Njonkou Tchoquessi — Baltimore, Maryland

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗