🏛️ Verified NIH Record • Updated 2025-09-22

Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout (NCT04875702)

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: Massachusetts General Hospital

🩺 Plain-English Summary (8th-Grade Level)

The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered gout outcomes, as well as relevant cardiovascular-metabolic-renal endpoints.

Who can join: Review the eligibility criteria below.

Location: The University of Alabama at Birmingham — South Birmingham, Alabama

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (7 Sites)

  • The University of Alabama at Birmingham — South Birmingham, Alabama
  • UCLA Health — Santa Monica, California
  • Massachusetts General Hospital — Boston, Massachusetts
  • Brigham and Women's Hospital (BWH) — Boston, Massachusetts
  • Boston Medical Center (BMC) — Boston, Massachusetts
  • NYU Langone — New York, New York
  • West Virginia University (Including Mobile Clinical Trials Unit) — Morgantown, West Virginia

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗