Who is eligible for clinical trial NCT04991519?

Participants must meet protocol criteria for Aphasia. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT04991519 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2024-11-07

Brain-based Understanding of Individual Language Differences After Stroke (NCT04991519)

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Georgetown University

🩺 Plain-English Summary (8th-Grade Level)

Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (7 items).

Location: Georgetown University Medical Center — Washington D.C., District of Columbia

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Stroke Survivors:
Age \>=18
Stroke in left hemisphere of brain with or without aphasia, or stroke elsewhere causing aphasia
Learned English at 8 years or younger Controls:
Age \>=18
No history of brain injury resulting from stroke, trauma, infection (i.e. encephalitis), or tumor
Learned English at 8 years or younger

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
History of other brain conditions that could impact interpretation of results (such as multiple sclerosis, premorbid dementia)
Severe psychiatric condition that would interfere with participation in the study
History of a learning disability that could impact interpretation of results Additional Exclusion Criteria for MRIs:
Pacemaker or magnetic metal in the body that is not MRI compatible
Pregnancy
Claustrophobia

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Georgetown University Medical Center — Washington D.C., District of Columbia

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗