🏛️ Verified NIH Record • Updated 2026-06-06
Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy)) (NCT05135091)
🟢 Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Neurona Therapeutics
🩺 Plain-English Summary (8th-Grade Level)
This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA).
Who can join: Review the eligibility criteria below.
Location: University of Alabama — Birmingham, Alabama
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (35 Sites)
- University of Alabama — Birmingham, Alabama
- Mayo Clinic Arizona Epilepsy Center — Phoenix, Arizona
- Banner-University of Arizona Medical Center Tucson Comprehensive Epilepsy Program — Tucson, Arizona
- University of Arkansas for Medical Sciences — Little Rock, Arkansas
- University of Southern California Keck Hospital — Los Angeles, California
- University of California Los Angeles — Los Angeles, California
- UC Irvine Medical Center — Orange, California
- Stanford University — Palo Alto, California
- University of California Davis — Sacramento, California
- University of California San Diego — San Diego, California
- University of California San Francisco — San Francisco, California
- University of Colorado Anschutz Medical Campus — Aurora, Colorado
- George Washington University — Washington D.C., District of Columbia
- University of Miami — Miami, Florida
- Rush University Medical Center — Chicago, Illinois
- University of Chicago — Chicago, Illinois
- University of Iowa Health Care — Iowa City, Iowa
- Ochsner Clinic Foundation — New Orleans, Louisiana
- Beth Israel Deaconess Medical Center — Boston, Massachusetts
- Wayne State University/Detroit Medical Center Comprehensive Epilepsy Program — Detroit, Michigan
- Washington University at St. Louis — St Louis, Missouri
- Dartmouth Hitchcock Medical Center/ Department of Neurology — Lebanon, New Hampshire
- Hofstra Northwell Comprehensive Epilepsy Center — Great Neck, New York
- NYU Langone Comprehensive Epilepsy Center — New York, New York
- SUNY Upstate Medical University — Syracuse, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.