EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction (NCT05284747)
🩺 Plain-English Summary (8th-Grade Level)
The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial infarction, ischemic stroke, arterial revascularization, and all-cause death in subjects hospitalized for an acute myocardial infarction (non-ST-segment elevation myocardial infarction \[NSTEMI\] and ST-segment elevation myocardial infarction \[STEMI\]).
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (2 items) and avoid the listed exclusions (3 items).
Location: University of Alabama at Birmingham — Birmingham, Alabama
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Participants requiring invasive hemodynamic and/or vasopressor/inotropic support at the time of screening
- Participants with elevated biomarkers of myocardial injury due to secondary/nonatherosclerotic etiology (eg, sepsis, atrial fibrillation, vasospasm, decompensated heart failure, uncontrolled hypertension, stress induced cardiomyopathy)
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (120 Sites)
- University of Alabama at Birmingham — Birmingham, Alabama
- Eastern Shore Research Institute — Fairhope, Alabama
- Heart Center Research LLC — Huntsville, Alabama
- Northern Arizona Healthcare Corporation Cardiovascular Institute — Flagstaff, Arizona
- Scottsdale Healthcare at Shea - HonorHealth — Scottsdale, Arizona
- Pima Heart and Vascular Clinical Research — Tucson, Arizona
- John Muir Health and Cardiovascular Institute — Concord, California
- VA Greater Los Angeles Healthcare System — Los Angeles, California
- University of California Los Angeles — Los Angeles, California
- University of California-Irvine — Orange, California
- University of Colorado Hospital — Aurora, Colorado
- Bridgeport Hospital — Bridgeport, Connecticut
- Hartford Hospital — Hartford, Connecticut
- Cardiology Associates of Fairfield County PC — Stamford, Connecticut
- Excel Medical Clinical Trials — Boca Raton, Florida
- Clearwater Cardiovascular Consultants — Clearwater, Florida
- University of Florida at Gainesville — Gainesville, Florida
- University of Florida and Shands Hospital — Jacksonville, Florida
- AdventHealth Orlando — Orlando, Florida
- Cardiology Partners Clinical Research Institute — Palm Beach Gardens, Florida
- Baptist Health Care — Pensacola, Florida
- Ascension Sacred Heart — Pensacola, Florida
- Clearwater Cardiovascular Consultants — Safety Harbor, Florida
- Tampa Cardiovascular Interventions and Research — Tampa, Florida
- Clinical Site Partners Orlando dba Flourish Research — Winter Park, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.