🏛️ Verified NIH Record • Updated 2026-02-05
Response of Cardiometabolic Biomarkers and Gut Microbiota to Walnut Consumption (NCT05321277)
🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: University of California, Davis
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this research is to test if eating walnuts will cause any changes in blood lipids (like good and bad cholesterol, for example) and levels of inflammation in the blood, as well as changes in the bacteria living in the gut.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (1 items) and avoid the listed exclusions (14 items).
Location: Ragle Human Nutrition Center — Davis, California
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Adults unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant or lactating women, women planning to become pregnant in the next four months and prisoners will be specifically excluded. Additional exclusion criteria are listed below:
- Allergy to walnuts or other nuts
- Eating more than 25 grams of fiber per day, assessed by the Block Dietary-Fruit-Vegetable-Fiber Screener©
- Taking medications or supplements known to affect metabolism or gut microbiota composition (i.e. Metformin, statins, antibiotics within the past 3 months, fiber supplements, probiotics, and others)
- Documented chronic diseases including diabetes, renal or liver disease, metabolic syndrome, active cancer, MI or stroke, history of gastric bypass or GI disease (e.g. Crohn's Disease, Irritable Bowel Disease, diverticulosis, diverticulitis, etc.)
- Smoker or living with a smoker, including vaporizer and/or electronic cigarettes.
- Illicit drug use, cannabis usage, or consuming \>1 alcoholic drink/day
- Extreme dietary or exercise patterns
- Recent weight fluctuations (\>10% in the last 6 months)
- Taking prescription lipid medications or supplements that may affect lipoprotein metabolism (i.e. \>1 g of fish oil/day, antioxidant supplements)
- Taking exogenous hormones
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Ragle Human Nutrition Center — Davis, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.