Influenza Human Challenge Model (NCT05332899)
🩺 Plain-English Summary (8th-Grade Level)
This study examines how the immune system responds to the flu virus (H3N2) during and after infection and how the flu virus is transmitted in the environment. The study will used a flu virus called the H3N2 influenza challenge virus which was produced specifically for use in clinical research in controlled conditions. The study will also assess the safety of the H3N2 influenza challenge in healthy subjects. Mild to moderate symptoms are expected based on previous studies with this strain of influenza.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (16 items) and avoid the listed exclusions (38 items).
Location: Hope Clinic — Atlanta, Georgia
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Have household contact with or have daily contact with:
- Children under 5 years of age
- Children and/or teenagers who are receiving long-term aspirin therapy
- Women who are pregnant or who are trying to become pregnant
- Persons older than 65 years of age
- Persons of any age with significant chronic medical conditions such as: chronic pulmonary disease, chronic cardiovascular disease, contacts who required medical follow-up or hospitalization during the past 5 years because of chronic metabolic disease, immunosuppression or cancer, neurological and neurodevelopmental conditions
- Are healthcare workers with patient contact in the 2 weeks after influenza challenge.
- Plan to be living in a confined environment (e.g. ship, camp, or dormitory) within 2 weeks after receiving the challenge strain.
- For females, are pregnant or plan to become pregnant at any time between the Screening Visit through the duration of the trial.
- Are breastfeeding or plan to breastfeed at any given time throughout the study.
- Have a body mass index (BMI) less than or equal to 18.5 and greater than or equal to 35.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (2 Sites)
- Hope Clinic — Atlanta, Georgia
- Emory University Hospital — Atlanta, Georgia
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.