Who is eligible for clinical trial NCT05384769?

Participants must meet protocol criteria for Lung Carcinoma. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT05384769 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-10-02

Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer (NCT05384769)

🟢 Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol Sponsor: City of Hope Medical Center

🩺 Plain-English Summary (8th-Grade Level)

This clinical trial investigates how practical and doable (feasibility) cell-free deoxyribonucleic acid (DNA) liquid biopsy is in screening high-risk patients for lung cancer. Currently, a low dose computed tomography (CT) scan is used to screen for lung cancer, however, due to various factors, few high-risk patients are screened. Liquid biopsy utilizes technology that can detect small amounts of DNA shed by cancer cells and may be able to spot lung cancer at an earlier stage. If a positive result comes back from the liquid biopsy, a patient may be more willing to get a low dose CT (LDCT) scan, possibly confirming the biopsy's findings and thus leading to more early lung cancer detection.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (8 items) and avoid the listed exclusions (5 items).

Location: City of Hope Medical Center — Duarte, California

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Documented written informed consent of the participant.
Age 50-80 years.
Smoking history of \>= 20 pack-years and if quit, quit within 15 years.
Received referral for counseling for lung cancer screening and would qualify for LDCT.
Health Insurance that will pay for a LDCT for lung cancer screening at either City of Hope Duarte, Newport Beach (Newport Diagnostic Imaging), or Lancaster (Renaissance Imaging/Antelope Valley Outpatient Imaging Center).
Willingness to provide blood sample.
English speaking.
Consent to undergo lung cancer screening with either liquid biopsy (LB) or LDCT.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Symptoms of lung cancer.
Chest CT scan or chest positron emission tomography (PET)/CT within 12 months.
Any cancer diagnosis within past 5 years, excluding non-melanoma skin cancer.
Unable to undergo LDCT at either City of Hope Duarte, Newport Beach, or Lancaster.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

City of Hope Medical Center — Duarte, California

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗