🏛️ Verified NIH Record • Updated 2026-06-17

Inhaled Corticosteroids (ICS) on Pulmonary Endothelial Function in COPD (NCT05607719)

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: University of Miami

🩺 Plain-English Summary (8th-Grade Level)

The study objective is to determine whether an ICS added for 4 weeks to a baseline treatment with a Long-Acting Beta-adrenergic Agonist (LABA) and Long-Acting Muscarinic Antagonist (LAMA) combination improves pulmonary vascular endothelial function as assessed by the vasodilator response to inhaled albuterol (endothelium-dependent vasodilation) in stable COPD patients treated with a LABA/LAMA without an ICS for at least one month.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (20 items).

Location: University of Miami — Miami, Florida

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • women of childbearing potential who do not use accepted birth- control measures
  • pregnant and breast-feeding women
  • respiratory infection within 4 weeks of a test day
  • a Corona Virus Disease (COVID) vaccination \<3 months prior to study entry
  • ICS use (within 4 weeks of study entry)
  • ICS hypersensitivity
  • albuterol intolerance
  • use of beta-blocker medication (oral and ophthalmic)
  • use of systemic glucocorticosteroid medication within 6 wk prior to the screening visit
  • an acute COPD exacerbation within 6 wk of the screening day (defined as a need for antibiotic or systemic glucocorticoid therapy or emergency department (ED) visit/hospitalization)
  • current smoking or vaping tobacco or other products

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

  • University of Miami — Miami, Florida

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗