🏛️ Verified NIH Record • Updated 2026-06-10

First in Human Study of AZD9592 in Solid Tumors (NCT05647122)

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This is a first-in-human (FIH) Phase I, multi-center, open-label, study of AZD9592, in patients with advanced solid tumors. The study consists of several study modules, each evaluating the safety, tolerability, preliminary efficacy, pharmacokinetics (PK), pharmacodynamics, anti-tumor activity, and immunogenicity of AZD9592, as monotherapy or in combination with anti-cancer agents.

Who can join: Review the eligibility criteria below.

Location: Research Site — Duarte, California

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (46 Sites)

  • Research Site — Duarte, California
  • Research Site — North Haven, Connecticut
  • Research Site — Washington D.C., District of Columbia
  • Research Site — Chicago, Illinois
  • Research Site — Baltimore, Maryland
  • Research Site — Baltimore, Maryland
  • Research Site — Milford, Massachusetts
  • Research Site — Mineola, New York
  • Research Site — New York, New York
  • Research Site — New York, New York
  • Research Site — New York, New York
  • Research Site — Philadelphia, Pennsylvania
  • Research Site — Providence, Rhode Island
  • Research Site — Houston, Texas
  • Research Site — Fairfax, Virginia
  • Research Site — Kogarah,
  • Research Site — Melbourne,
  • Research Site — Edmonton, Alberta
  • Research Site — Toronto, Ontario
  • Research Site — Beijing,
  • Research Site — Chongqing,
  • Research Site — Guangzhou,
  • Research Site — Wuhan,
  • Research Site — Marseille,
  • Research Site — Rennes,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗