Who is eligible for clinical trial NCT05665244?

Participants must meet protocol criteria for Upper-Airway Cough Syndrome. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT05665244 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-01-28

Laryngeal Cryotherapy for Refractory Neurogenic Cough (NCT05665244)

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: University of Texas Southwestern Medical Center

🩺 Plain-English Summary (8th-Grade Level)

This study aims to evaluate the safety and efficacy of upper aerodigestive tract cryotherapy treatment in patients with refractory neurogenic cough in a prospective pilot study with a validated patient reported outcome measure

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (14 items).

Location: UT Southwestern Medical Center — Dallas, Texas

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Adult patients 18 years or older with diagnosis of neurogenic cough
Neurogenic cough is a diagnosis of exclusion applied to persistent cough (8 weeks or longer)
Negative workup for other causes, including sinonasal allergies/chronic sinusitis, cough-variant asthma, and GERD
Patient willing to participate in a clinical trial

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Uncontrolled reflux (scoring on Reflux Symptom index of 13 or higher)
Vocal fold abnormalities or impairment
History of asthma or other underlying lung condition not adequately treated or controlled
Uncontrolled Allergic Rhinitis (Total Nasal Symptom Score \>6, which would indicate moderate disease32)
Reported symptom of postnasal drip
Current smoker
Current neuromodulator medication use
Patient unwilling to participate in clinical trial or sign an informed consent
End stage medical disease with poor life expectancy
Medical instability deemed by the investigators as a contraindication for enrollment
Abnormal Chest X-ray

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

UT Southwestern Medical Center — Dallas, Texas

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗