🏛️ Verified NIH Record • Updated 2026-08-20

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors (NCT05797168)

🟢 Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: AstraZeneca

🩺 Plain-English Summary (8th-Grade Level)

This research is designed to determine if experimental treatment with Antibody-drug conjugate, AZD5335, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced tumors

Who can join: Review the eligibility criteria below.

Location: Research Site — Duarte, California

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (60 Sites)

  • Research Site — Duarte, California
  • Research Site — Irvine, California
  • Research Site — La Jolla, California
  • Research Site — Aurora, Colorado
  • Research Site — Louisville, Kentucky
  • Research Site — Boston, Massachusetts
  • Research Site — Detroit, Michigan
  • Research Site — Columbus, Ohio
  • Research Site — Portland, Oregon
  • Research Site — Providence, Rhode Island
  • Research Site — Providence, Rhode Island
  • Research Site — Houston, Texas
  • Research Site — Fairfax, Virginia
  • Research Site — Liverpool,
  • Research Site — Melbourne,
  • Research Site — Edmonton, Alberta
  • Research Site — London, Ontario
  • Research Site — Toronto, Ontario
  • Research Site — Montreal, Quebec
  • Research Site — Montreal, Quebec
  • Research Site — Chengdu,
  • Research Site — Chongqing,
  • Research Site — Guangzhou,
  • Research Site — Guangzhou,
  • Research Site — Jinan,

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗