Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation (NCT05806515)
๐ฉบ Plain-English Summary (8th-Grade Level)
This phase II trial tests how well carboplatin before surgery works in treating patients with high-risk prostate cancer and an inherited BRCA1 or BRCA2 gene mutation. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowing the growth of tumor cells. Giving carboplatin before surgery may shrink tumors in patients with high-risk prostate cancer with BRCA1 and BRCA2 gene mutations.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (26 items) and avoid the listed exclusions (5 items).
Location: Anchorage Associates in Radiation Medicine โ Anchorage, Alaska
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Participant must not have evidence of distant metastatic disease by conventional imaging within 90 days prior to registration
- NOTE: cN1 detected only by PSMA-PET is permitted if urologist deems sites of disease to be potentially completely resectable
- Participant must not have received prior radiation therapy (RT) to the pelvic region
- Participant must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of protocol treatment
๐ Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
๐ All Participating Trial Locations (133 Sites)
- Anchorage Associates in Radiation Medicine โ Anchorage, Alaska
- Anchorage Radiation Therapy Center โ Anchorage, Alaska
- Alaska Breast Care and Surgery LLC โ Anchorage, Alaska
- Alaska Oncology and Hematology LLC โ Anchorage, Alaska
- Alaska Women's Cancer Care โ Anchorage, Alaska
- Anchorage Oncology Centre โ Anchorage, Alaska
- Katmai Oncology Group โ Anchorage, Alaska
- Providence Alaska Medical Center โ Anchorage, Alaska
- Cancer Center at Saint Joseph's โ Phoenix, Arizona
- Mission Hope Medical Oncology - Arroyo Grande โ Arroyo Grande, California
- Providence Saint Joseph Medical Center/Disney Family Cancer Center โ Burbank, California
- Mercy Cancer Center ๏ฟฝ๏ฟฝ Carmichael โ Carmichael, California
- Mercy San Juan Medical Center โ Carmichael, California
- City of Hope Comprehensive Cancer Center โ Duarte, California
- Mercy Cancer Center - Elk Grove โ Elk Grove, California
- City of Hope at Irvine Lennar โ Irvine, California
- Providence Queen of The Valley โ Napa, California
- Mercy Cancer Center - Rocklin โ Rocklin, California
- Mercy Cancer Center - Sacramento โ Sacramento, California
- Pacific Central Coast Health Center-San Luis Obispo โ San Luis Obispo, California
- Mission Hope Medical Oncology - Santa Maria โ Santa Maria, California
- Providence Medical Foundation - Santa Rosa โ Santa Rosa, California
- Providence Santa Rosa Memorial Hospital โ Santa Rosa, California
- Woodland Memorial Hospital โ Woodland, California
- Penrose-Saint Francis Healthcare โ Colorado Springs, Colorado
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.