🏛️ Verified NIH Record • Updated 2025-09-17

Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients (NCT05829317)

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: Dr. Stephanie Sibley

🩺 Plain-English Summary (8th-Grade Level)

A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (6 items) and avoid the listed exclusions (12 items).

Location: St Joseph's Healthcare Hamilton — Hamilton, Ontario

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria
  • Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours
  • Receiving IMV for airway protection only (for example, isolated head trauma)
  • Active atrial fibrillation at the time of enrolment
  • On oral or continuous infusion of Amiodarone
  • Unlikely to survive \>24 hours or palliative patients
  • Cardiac surgery patients
  • Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma)
  • Patients receiving dialysis
  • Positive pregnancy test (females \<50 years old)
  • Previously enrolled in this trial
  • Treating physician refuses enrollment

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (4 Sites)

  • St Joseph's Healthcare Hamilton — Hamilton, Ontario
  • Kingston Health Sciences Centre — Kingston, Ontario
  • The Ottawa Hospital - General Campus — Ottawa, Ontario
  • The Ottawa Hospital - Civic Campus — Ottawa, Ontario

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗