A Study to Learn How Well Dupilumab Works in Adult and Adolescent Participants With Eosinophilic Gastritis With or Without Eosinophilic Duodenitis and the Side Effects it May Have (NCT05831176)
🩺 Plain-English Summary (8th-Grade Level)
This study is researching an experimental drug called dupilumab. The study is focused on participants with active eosinophilic gastritis (EoG) with or without eosinophilic duodenitis (EoD). Participants with EoD only are not eligible for enrollment. EoG and EoD are uncommon, persistent, allergic/immune diseases in which eosinophils (a type of white blood cell) gather in large numbers in the stomach and small intestine and cause inflammation and damage. The aim of the study is to evaluate the effect of dupilumab on relieving EoG (with or without EoD) symptoms and reducing inflammation in the stomach and, if applicable, small intestine in adults and adolescents aged 12 years and older after at least 24 weeks (about 6 months) and up to 52 weeks (1 year) of treatment. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Who can join: Review the eligibility criteria below.
Location: Phoenix Childrens Hospital — Phoenix, Arizona
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (53 Sites)
- Phoenix Childrens Hospital — Phoenix, Arizona
- Om Research LLC — Apple Valley, California
- Scripps Clinic — La Jolla, California
- Om Research LLC — Lancaster, California
- University of California - Los Angeles (UCLA) — Los Angeles, California
- University of Southern California Keck School of Medicine — Los Angeles, California
- GastroIntestinal BioSciences — Los Angeles, California
- United Medical Doctors — Murrieta, California
- Ucsf Medical Center (Benioff Childrens Hospital) — San Francisco, California
- University of Colorado Anschutz Health Science Building (AHSB) CU Research Pharmacy — Aurora, Colorado
- Connecticut Clinical Research Institute — Bristol, Connecticut
- UConn Health — Farmington, Connecticut
- Encore Borland-Groover Clinical Research — Jacksonville, Florida
- Northwestern University — Chicago, Illinois
- University Of Kansas — Kansas City, Kansas
- Beth Israel Deaconess Medical Center (BIDMC) Harvard Medical School — Boston, Massachusetts
- University of Michigan — Ann Arbor, Michigan
- MNGI Digestive Health P.A. — Plymouth, Minnesota
- Mayo Clinic Hospital Rochester — Rochester, Minnesota
- Advanced Research Institute — Reno, Nevada
- Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire
- Northwell Health — Great Neck, New York
- Icahn School of Medicine at Mount Sinai (ISMMS) - The Mount Sinai Hospital (MSH) — New York, New York
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina
- Charlotte Gastroenterology & Hepatology, PLLC — Charlotte, North Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.