Who is eligible for clinical trial NCT05929794?

Participants must meet protocol criteria for Healthy. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT05929794 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-06-12

Pharmacokinetics of Transdermal Metronidazole (NCT05929794)

🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: University of Iowa

🩺 Plain-English Summary (8th-Grade Level)

This is a crossover pharmacokinetic clinical study in healthy volunteers to compare metronidazole delivery through skin when a gel or cream metronidazole product is applied to skin treated with a micropatch.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (8 items) and avoid the listed exclusions (22 items).

Location: University of Iowa — Iowa City, Iowa

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Men or non-pregnant women ≥18 years old, of any ethnic background
Provide written informed consent before initiation of any study procedures
Available for follow-up for the planned duration of the study
Able to communicate well with the investigators
Able to adhere to the study protocol schedule, study restrictions and examination schedule
Subjects deemed to be healthy, as determined by the study physician, based on medical history, current medical conditions, and medication history
Agrees not to participate in another clinical study during the study period unless the study is in the follow up phase and it has been 1 month since the subject received any experimental agents or treatments. The subject also agrees not to participate in an investigational drug study for at least 1 month after last procedure day
Agrees not to donate blood to a blood bank throughout participation in the study and for at least 2 months after last procedure day.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Unable to give consent
Inability to communicate or cooperate with the investigators
Known previous adverse reaction to microneedle insertion
Known allergy or adverse reaction to medical tape/adhesive, or aloe vera
Women who are pregnant or lactating
Abnormal vital signs or lab values deemed to be medically significant by the study physician or Principal Investigator
Positive urine drug screening test
Known prior serious adverse reaction or hypersensitivity to metronidazole or any metronidazole products
History of anaphylaxis to an antibiotic, antimicrobial, antifungal, antipartisitic, or antiviral drug
Current smoker or regular use of nicotine or tobacco products
Participation in any ongoing investigational drug trial or clinical drug trial unless the study is in the follow up phase and it has been ≥1 month since the subject received any experimental agents or treatments

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

University of Iowa — Iowa City, Iowa

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗