Who is eligible for clinical trial NCT06025630?

Participants must meet protocol criteria for Hypertension. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06025630 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-03-24

Targeting Endoplasmic Reticulum Stress in Human Hypertension (NCT06025630)

🟢 Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: University of North Texas Health Science Center

🩺 Plain-English Summary (8th-Grade Level)

There is strong evidence suggesting that endoplasmic reticulum stress contributes to neurogenic and vascular hypertension in various animal models, however this has never been explored in humans. Therefore, this project will fill this gap by performing a single-blind, placebo-controlled trial in humans with hypertension.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (27 items).

Location: University of North Texas Health Science Center — Fort Worth, Texas

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

18 to 80 years of age
No tobacco/nicotine use within preceding 6 months (e.g., cigarettes, chewing tobacco, nicotine gum or patches)
Systolic blood pressure \<140 mmHg; diastolic blood pressure \<90 mmHg (obtained at the Screening and Familiarization Visit)
Normal 12-lead ECG (obtained at the Screening and Familiarization Visit and reviewed by a board-certified physician)
Normal clinical results from a medical exam reviewed by a board-certified physician (e.g., General Health Questionnaire obtained at the Screening and Familiarization Visit)
Body mass index (BMI) \<35 unless athletic/muscular build; calculation = body weight (kg)/height (m2);
Females only: documentation of a negative pregnancy test prior to the familiarization and experimental sessions unless post-menopausal

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Not meeting the defined age criteria
Body mass index (BMI) \>35 unless athletic/muscular build; calculation = body weight (kg)/height (m2)
Any tobacco/nicotine use within the last 6 months (e.g., cigarettes, chewing tobacco, nicotine gum or patches)
Positive pregnancy test
Females with an erratic/irregular menstrual cycle
Females who are breastfeeding
Women who are prescribed a continually releasing hormonal contraceptive (e.g. NuvaRingTM or other hormone releasing vaginal rings, Depo Provera shot, or birth control implants such as Nexplanon)
Subjects who weigh less than 80 lbs.
Use of prescription drugs, non-prescription drugs, dietary supplements or herbal medicines known to alter vascular function unless cleared prior to the study
Use of beta blockers
Daily use of bronchodilators

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

University of North Texas Health Science Center — Fort Worth, Texas

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗