🏛️ Verified NIH Record • Updated 2026-06-08

Study to Assess the Safety and Effectiveness of NMRA-335140-501 (NCT06029439)

🔵 Active, Not Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Neumora Therapeutics, Inc.

🩺 Plain-English Summary (8th-Grade Level)

This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder (MDD). Participants who completed a parent study investigating the efficacy and safety of NMRA-335140 as a treatment for MDD (ie, NMRA-335140-301, NMRA-335140-302, or NMRA-335140-303), and complete the 6 weeks double-blind treatment, provide informed consent, and meet eligibility criteria, may enter this extension study.

Who can join: Review the eligibility criteria below.

Location: Neumora Investigator site — Huntsville, Alabama

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (178 Sites)

  • Neumora Investigator site — Huntsville, Alabama
  • Neumora Investigator Site — Phoenix, Arizona
  • Neumora Investigator Site — Bentonville, Arkansas
  • Neumora Investigator Site #1 — Little Rock, Arkansas
  • Neumora Investigator site — Little Rock, Arkansas
  • Neumora Investigator Site — Rogers, Arkansas
  • Neumora Investigator site — Bellflower, California
  • Neumora Investigator Site — Cerritos, California
  • Neumora Investigator Site — Encino, California
  • Neumora Investigator Site — Garden Grove, California
  • Neumora Investigator Site — Glendale, California
  • Neumora Investigator Site — Imperial, California
  • Neumora Investigator Site — Irvine, California
  • Neumora Investigator Site — Lafayette, California
  • Neumora Investigator Site #1 — Long Beach, California
  • Neumora Investigator site — Long Beach, California
  • Neumora Investigator Site — Los Angeles, California
  • Neumora Investigator Site — Newport Beach, California
  • Neumora Investigator Site — Oceanside, California
  • Neumora Investigator Site #1 — Orange, California
  • Neumora Investigator Site — Orange, California
  • Neumora Investigator Site — Riverside, California
  • Neumora Investigator Site — San Diego, California
  • Neumora Investigator Site — San Francisco, California
  • Neumora Investigator Site — San Jose, California

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗