🏛️ Verified NIH Record • Updated 2025-04-01
Open Label - Personalized Therapeutic Neuromodulation for Anhedonic Depression (NCT06052137)
🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Stanford University
🩺 Plain-English Summary (8th-Grade Level)
This study will investigate the anti-anhedonic efficacy of a novel neurostimulation strategy termed accelerated intermittent theta burst stimulation (aiTBS) in participants with treatment resistant depression (TRD).
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (13 items) and avoid the listed exclusions (19 items).
Location: Stanford University — Stanford, California
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Pregnancy
- History of or current psychotic disorder or bipolar disorder
- Severe borderline personality disorder.
- Diagnosis of Intellectual Disability or Autism Spectrum Disorder
- Primary psychiatric condition other than MDD requiring treatment except stable comorbid anxiety disorder
- Current moderate or severe substance use disorder or demonstrating signs of acute substance withdrawal
- Urine screening test positive for illicit substances
- Acute suicide risk based on clinical judgement or a suicide attempt (as defined by the C-SSRS) within the past one year
- Any history of ECT (greater than 8 sessions) without meeting responder criteria
- Recent (within 4 weeks of any clinical effect) or concurrent use of rapid acting antidepressant agent (i.e., ketamine or a course of ECT)
- History of significant neurologic disease, including dementia, Parkinson's or Huntington's disease, brain tumor, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Stanford University — Stanford, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.