Who is eligible for clinical trial NCT06110897?

Participants must meet protocol criteria for Major Depressive Disorder. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06110897 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-04-30

RESISTance Exercise for Depression Trial (NCT06110897)

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program Sponsor: University of Wisconsin, Madison

🩺 Plain-English Summary (8th-Grade Level)

Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (10 items).

Location: Iowa State University — Ames, Iowa

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Be diagnosed with DSM-5 MDD, confirmed via Structured Clinical Interview for DSM-5 (SCID).
Have current depressive symptoms of at least mild severity defined by the Hamilton Rating Scale of Depression 17 greater than or equal to 8 (HAMD; using the GRID-HAMD evaluated by trained, masked raters)
Be ages 18-65
EITHER not taking any mental health medications or seeking other mental health treatment (e.g., behavioral, psychological) OR be on a stable mental health medication and/or treatment regimen for the past 8 weeks, and intend to maintain that regimen for the duration of the study
Safe to exercise based on physical activity screening questions or physician clearance
Willing to be randomized to either condition
have a Smartphone

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Currently pregnant, nursing, or planning to become pregnant during the trial
Class III+ obesity
Diagnosed with lifetime or current Psychosis, Mania, or Bipolar Disorder, via the SCID
Diagnosed with current Substance Use Disorder, via the SCID
Active suicidal ideation with specific plan and intent ('5' score on Suicidal Ideation from Columbia Suicide Severity Rating Scale), which would necessitate immediate emergent care
Exhibit behavioral disturbance (e.g., aggression, mild-moderate cognitive impairment) that would significantly interfere with study participation, as assessed by clinical research personnel
Currently meets resistance exercise recommendations (2 days per week) for the last 8 weeks
Self-reporting a concussion/traumatic brain injury within the last 3 months
Having cardiovascular disease, uncontrolled hypertension, or uncontrolled diabetes

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (2 Sites)

Iowa State University — Ames, Iowa
University of Wisconsin - Madison — Madison, Wisconsin

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗