A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight (NCT06143956)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (12 items).
Location: The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler, Arizona
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
- Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
- Have poorly controlled hypertension.
- Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
- Have any of the following cardiovascular conditions within 3 months prior to screening:
- acute myocardial infarction
- cerebrovascular accident (stroke)
- unstable angina, or
- hospitalization due to congestive heart failure.
- Have a history of symptomatic gallbladder disease within the past 2 years.
- Have a lifetime history of suicide attempts.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (54 Sites)
- The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler, Arizona
- HOPE Research Institute — Phoenix, Arizona
- Headlands Research - Scottsdale — Scottsdale, Arizona
- The Institute for Liver Health II dba Arizona Liver Health-Tucson — Tucson, Arizona
- NorCal Medical Research, Inc — Greenbrae, California
- Velocity Clinical Research, Huntington Park — Huntington Park, California
- Peninsula Research Associates — Rolling Hills Estates, California
- Diablo Clinical Research, Inc. — Walnut Creek, California
- Stamford Therapeutics Consortium — Stamford, Connecticut
- Northeast Research Institute (NERI) — Fleming Island, Florida
- New Horizon Research Center — Miami, Florida
- Indago Research & Health Center, Inc — Miami Lakes, Florida
- Suncoast Clinical Research, Inc. — New Port Richey, Florida
- Charter Research - Winter Park — Orlando, Florida
- Charter Research - Lady Lake — The Villages, Florida
- Pacific Diabetes & Endocrine Center — Honolulu, Hawaii
- Medical Research Partners — Ammon, Idaho
- Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois
- Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois
- NorthShore University Health System — Skokie, Illinois
- Iowa Diabetes and Endocrinology Research Center — West Des Moines, Iowa
- Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas
- Monroe Biomedical Research - Louisville — Louisville, Kentucky
- Knownwell — Needham, Massachusetts
- Lucida Clinical Trials — New Bedford, Massachusetts
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.