🏛️ Verified NIH Record • Updated 2026-07-13
A Study of Oral Kavalactones Effect on Nurses (NCT06177535)
🔵 Active, Not Recruiting Observational / Diagnostic 💊 Investigational Drug / Biologic Sponsor: Mayo Clinic
🩺 Plain-English Summary (8th-Grade Level)
This research study is being done to assess the impact of taking Kava extract (Piper methysticum), a dietary supplement on cortisol in a healthy nursing population.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (18 items).
Location: Mayo Clinic Minnesota — Rochester, Minnesota
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Pregnant, nursing, or trying to conceive.
- Persons with a menstrual cycle who are not willing and able to use an approved contraceptive during the study (female sterilization (tubal ligation, hysterectomy), IUD or another implant, oral or injectable contraceptive, contraceptive patch/ring, diaphragm/cervical cap, male sterilization (vasectomy), male condom, female condom, sponge/spermicide) (Persons who do not have sex with men can participate without the use of an approved contraceptive).
- Use of kava or kava-containing products within the past 8 weeks.
- Any prior adverse reaction or known sensitivity or allergy to kava or related botanicals (peppers).
- Use of acetaminophen that cannot be discontinued or replaced with an NSAID during the study.
- Use of oral corticosteroids (e.g., hydrocortisone) or other steroids (e.g., prednisone).
- Alcohol use greater than 1 drink per day.
- Use of kratom within the past 8 weeks.
- Recent history of clinical depression or anxiety diagnosis.
- Known significant liver disease or dysfunction.
- Known significant kidney disease or dysfunction.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Mayo Clinic Minnesota — Rochester, Minnesota
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.