Who is eligible for clinical trial NCT06217198?

Participants must meet protocol criteria for Depression. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06217198 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-06

A Computerized Depression Intervention in Veterans (NCT06217198)

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program Sponsor: VA Office of Research and Development

🩺 Plain-English Summary (8th-Grade Level)

Depressive symptoms are common among Veterans and associated with significant impairment. Timely intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet can be completed remotely at any time, and thus minimize burden on Veterans, however the research examining their utility in Veterans is limited. This proposed project will examine Deprexis, a self-guided internet-delivered intervention, which targets depressive symptoms and associated functional impairments. Interviews will be conducted to gain insight into Veterans' perceptions, needs, and preferences vis-a-vis Deprexis, with results informing a randomized controlled trial. Here an 8-week course of Deprexis will be compared to a treatment-as-usual (TAU) control condition to establish if Deprexis is acceptable and effective for Veterans with mild to moderate depressive symptoms. Veterans engaged in Deprexis are hypothesized to show improvements on measures of functioning and decreases in depressive symptoms compared to the TAU control group. The proposed work has great clinical utility, as it could provide a readily accessible, high-quality intervention for the many Veterans suffering from depressive symptoms, with the potential to improve functioning and long-term outcomes.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (4 items).

Location: Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX — Waco, Texas

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Potential participants include male and female Veterans of all races/ethnicities who are:
able to comprehend and sign the informed consent form
have reliable access to the internet and a computer, tablet and/or smartphone
exhibit mild or moderate, but not very severe, levels of depression
stable on psychotropic medications

Usually NOT eligible if any of the following apply:

Exclusion Criteria: Aim 1 and Aim 2: Veterans will be excluded from study participation if they:
endorse any positive symptoms of a psychotic disorder
screen positive for Bipolar I Disorder
report current suicidal risk

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX — Waco, Texas

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗