Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment (NCT06235697)
🩺 Plain-English Summary (8th-Grade Level)
This study is being done to answer the following question: Is the strategy to give higher doses of radiotherapy treatment over a shorter period of time using special equipment and fewer treatments (also known as Stereotactic Body Radiation Therapy or SBRT) as effective as usual external radiation therapy given with a brachytherapy boost (which involves radiation sources inserted directly into the prostate)?
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (29 items) and avoid the listed exclusions (9 items).
Location: Kaiser Permanente-Deer Valley Medical Center — Antioch, California
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Prior pelvic radiotherapy
- Contraindication to radical prostate radiotherapy (e.g. connective tissue disease or inflammatory bowel disease)
- Anticoagulation medication (if unsafe to discontinue for gold seed insertion or brachytherapy implant) and/or prior or current bleeding diathesis
- Prior steam vaporization (Rezum), transurethral resection of the prostate (TURP), prostatectomy (simple or radical), or any ablative therapy to the prostate (cryotherapy, HIFU, TULSA, focal laser ablation, photodynamic therapy)
- Prostate volume \> 60cc before start of androgen deprivation therapy
- Anatomy that would preclude precise brachytherapy implant (such as arch interference or large median lobe)
- Evidence of castrate resistance (defined as a rising PSA \> 3.0 ng/ml while testosterone is \< 3.0 nmol/l)
- Hip prosthesis (unilateral hip replacement is allowed if dose constrains can be reasonably achieved.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (57 Sites)
- Kaiser Permanente-Deer Valley Medical Center — Antioch, California
- Kaiser Permanente Dublin — Dublin, California
- Kaiser Permanente-Fremont — Fremont, California
- Kaiser Permanente Fresno Orchard Plaza — Fresno, California
- Kaiser Permanente-Fresno — Fresno, California
- Kaiser Permanente-Modesto — Modesto, California
- Kaiser Permanente Oakland-Broadway — Oakland, California
- Kaiser Permanente-Oakland — Oakland, California
- Kaiser Permanente- Marshall Medical Offices — Redwood City, California
- Kaiser Permanente-Richmond — Richmond, California
- Rohnert Park Cancer Center — Rohnert Park, California
- Kaiser Permanente-Roseville — Roseville, California
- The Permanente Medical Group-Roseville Radiation Oncology — Roseville, California
- Kaiser Permanente Downtown Commons — Sacramento, California
- Kaiser Permanente-South Sacramento — Sacramento, California
- Kaiser Permanente-San Francisco — San Francisco, California
- Kaiser Permanente-Santa Teresa-San Jose — San Jose, California
- Kaiser Permanente San Leandro — San Leandro, California
- Kaiser San Rafael-Gallinas — San Rafael, California
- Kaiser Permanente Medical Center - Santa Clara — Santa Clara, California
- Kaiser Permanente-Santa Rosa — Santa Rosa, California
- Kaiser Permanente Cancer Treatment Center — South San Francisco, California
- Kaiser Permanente-South San Francisco — South San Francisco, California
- Kaiser Permanente-Stockton — Stockton, California
- Kaiser Permanente Medical Center-Vacaville — Vacaville, California
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.