🏛️ Verified NIH Record • Updated 2026-07-10
DORA and LP in Alzheimer's Disease Biomarkers (NCT06274528)
🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: University of Minnesota
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to see if the sleep aid, lemborexant, can decrease the amount of amyloid-beta and tau in the blood. Amyloid-beta and tau are proteins involved in the disease process leading to Alzheimer's disease.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (34 items).
Location: Washington University in St. Louis, School of Medicine — St Louis, Missouri
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- History or reported symptoms suggestive of restless legs syndrome, narcolepsy, or parasomnia.
- STOP-Bang score \>6 for participants without PAP.
- Untreated sleep apnea AHI\>15
- Poorly treated sleep apnea due to noncompliance or an AHI ≥ 10. \- PAP compliance is defined as ≥ 4 hours per night \>70% of the nights.
- Plasma p-Tau217/np-Tau217% \<2.5
- Stroke.
- History of renal impairment
- Defined as older adult patients with markers of kidney damage or eGFR \< 45.0 ml/min/1.73m2.
- Normal Limits ≥ 45.0 mL/min/1.73m2
- History of hepatic impairment
- AST and/or ALT ≥ 2X upper limit of normal (ULN).
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Washington University in St. Louis, School of Medicine — St Louis, Missouri
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.