🏛️ Verified NIH Record • Updated 2026-01-09

Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure (NCT06299436)

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Johns Hopkins University

🩺 Plain-English Summary (8th-Grade Level)

Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (8 items).

Location: Johns Hopkins Hospital — Baltimore, Maryland

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria:
  • Unable to interrupt VKA anticoagulation
  • Point of care International Normalized Ratio (INR) \> 1.5
  • Pregnant patients
  • Acute hospitalization or decompensation within 2 weeks prior to study date
  • Participation in a study involving an investigational drug within 4 weeks prior to study date
  • Inability to lie flat in the supine position
  • Symptomatic hemodynamic instability at rest or during the procedure

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

  • Johns Hopkins Hospital — Baltimore, Maryland

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗