Early Onset Colorectal Cancer Detection (NCT06342401)
🩺 Plain-English Summary (8th-Grade Level)
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (4 items).
Location: City of Hope Medical Center — Duarte, California
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Hereditary colorectal cancer syndromes (identified through genetic testing)
- Inflammatory bowel diseases
- Lack of written informed consent
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (13 Sites)
- City of Hope Medical Center — Duarte, California
- IRCCS San Raffaele — Milan,
- Kawasaki University — Kawasaki,
- Mie University — Mie,
- National Cancer Center Hospital — Tokyo,
- Tokyo Medical and Dental University — Tokyo,
- Yamagata University — Yamagata,
- Barcelona University — Barcelona,
- Colorectal Surgery, Vall d'Hebron University Hospital, Universitat Autonoma de Barcelona UAB — Barcelona,
- Surgery Department, Hospital del Mar, Barcelona, Spain — Barcelona,
- Salamanca Biomedical Research Institute — Madrid,
- University of Salamanca-SACYL-CSIC, Salamanca, Spain — Salamanca,
- University of La Laguna — San Cristóbal de La Laguna,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.