Who is eligible for clinical trial NCT06357234?

Participants must meet protocol criteria for Spinal Fusion. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06357234 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-04-22

Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery (NCT06357234)

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: IWK Health Centre

🩺 Plain-English Summary (8th-Grade Level)

This research trial will measure how useful Aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (9 items).

Location: IWK Health Sciences Center — Halifax, Nova Scotia

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Posterior Spinal Instrumentation and Fusion (PSIF) for idiopathic scoliosis
The fusion must include at least 6 vertebral levels.
Children greater than or equal to 8 years old, and less than 19 years old on the day of surgery
Weight \> 40kg - for ease of pharmacy preparation (PONV dose 1mg per kg to max 40mg)

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Patient/ Parent refusal
Hypersensitivity to Aprepitant or any ingredient in the formulation or oral solution. (previous allergy or adverse reaction to Aprepitant)
Developmental delay as reported by parents
Pregnant - Pregnancy test done as standard of care pre-operative
Severe systemic disease ASA classification III or greater
Concurrent use of any medication with severe interaction with Aprepitant as outlined in product monograph.
Neuromuscular or congenital scoliosis
Inability to take PO medications

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

IWK Health Sciences Center — Halifax, Nova Scotia

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗