Who is eligible for clinical trial NCT06376994?

Participants must meet protocol criteria for Chronic Obstructive Pulmonary Disease (COPD). Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06376994 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-07-30

Multi-Center Clean Air Randomized Controlled Trial in COPD (NCT06376994)

🟢 Recruiting Phase3 ⚙️ Medical Device Protocol Sponsor: JHSPH Center for Clinical Trials

🩺 Plain-English Summary (8th-Grade Level)

This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk and improving quality of life, functional status, rescue medication use.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (10 items).

Location: University of Alabama, Lung Health Center — Birmingham, Alabama

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

To be eligible, subjects must meet all these criteria:
Age ≥ 40 years.
Self-report of physician diagnosis of COPD.
Spirometry confirmed airway obstruction (post-bronchodilator spirometry of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) \< 0.7) as defined by the Global Initiative for Obstructive Lung Disease (GOLD) criteria (6, 11)
Tobacco exposure ≥ 10 pack-years. This refers to regular cigarette tobacco consumption.
Self-reported former smoker of at least 6 months' duration. This does not include e-cigarette use.
COPD Assessment Test (CAT) score ≥ 10, Modified Medical Research Council dyspnea scale (mMRC) ≥ 2, or history of moderate or severe exacerbation in the past 12 months (as defined by history of receiving a course of systemic corticosteroids or antibiotics for respiratory problems; or visiting an emergency department or being hospitalized for a COPD exacerbation within the past 12 months.)

Usually NOT eligible if any of the following apply:

Exclusion criteria To be eligible, subjects must not meet any one of these criteria:
Living in a location other than home (e.g., long-term care facility, nursing home)
Other chronic lung diseases, except asthma
Condition with less than a year of life expectancy (e.g., metastatic cancer) or in hospice
Spends \>2 months per year in location other than home; or plans to change residence in the next 12 months
Pregnant or breastfeeding
Current air cleaner use in the home (\*If the individual is willing to discontinue use of the personal air cleaner, this person can be eligible if all other eligibility has been met)
Inability to bring air cleaners (about 15 pounds each) into home, either by self, friend, or relative
Deemed by the study investigator to be unable to complete study protocol, including likely lack of internet connectivity
Participating in another interventional clinical trial

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (11 Sites)

University of Alabama, Lung Health Center — Birmingham, Alabama
University of California, Los Angeles — Los Angeles, California
University of Iowa — Iowa City, Iowa
University of Maryland — Baltimore, Maryland
Johns Hopkins — Baltimore, Maryland
Tidal Health — Salisbury, Maryland
Beth Israel Deaconess Medical Center — Boston, Massachusetts
University of Michigan — Ann Arbor, Michigan
Dartmouth Hitchcock — Lebanon, New Hampshire
Cleveland Clinic — Cleveland, Ohio
Reading Hospital — West Reading, Pennsylvania

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗